Difference between revisions of "Pathway enrichment in DNAse1 footprinting data"
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| − | '''Background''': Unraveling the transcriptional network in human cells is of great interest in genetics. A new publicly available data | + | '''Background''': Unraveling the transcriptional network in human cells is of great interest in genetics. A new publicly available data source with genome wide coverage released by the ENCODE Project has the potential to really advance our understanding of transcription regulations |
'''Goal''': Using these data sources, we will try to rediscover well known functional knowledge about transcription factors by just using this data set. If this is successful, we will expand our analysis to make novel predictions about functional involvment of transcription factors. | '''Goal''': Using these data sources, we will try to rediscover well known functional knowledge about transcription factors by just using this data set. If this is successful, we will expand our analysis to make novel predictions about functional involvment of transcription factors. | ||
Revision as of 18:01, 21 February 2013
Background: Unraveling the transcriptional network in human cells is of great interest in genetics. A new publicly available data source with genome wide coverage released by the ENCODE Project has the potential to really advance our understanding of transcription regulations
Goal: Using these data sources, we will try to rediscover well known functional knowledge about transcription factors by just using this data set. If this is successful, we will expand our analysis to make novel predictions about functional involvment of transcription factors.
Mathematical tools: Statistics. The students will learn about enrichment analysis and make contact with bias and variance issues in a practical setting. The students will learn about and perform large scale data analysis. Care is taken, that handling of the data is as simple as possible.
Biological or Medical aspects:
Supervisors: Aurelien Mace & David Lamparter
Students:
Presentation:Media:PresentationForStudents21_2_13.pdf see Genome Wide Association Studies, Media: McCarthy_review_GWAS.pdf , GWAS papers
Back to UNIL BSc course: "Solving Biological Problems that require Math 2012"
