Difference between revisions of "Genetics of liver enzymes levels"
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=== Background === | === Background === | ||
| − | The liver is a vital organ in the abdomen. It harbors a wide range of functions, from metabolites detoxification to secretion of digestive biochemicals. | + | The liver is a vital organ in the abdomen. It harbors a wide range of functions, from metabolites detoxification to secretion of digestive biochemicals. Three enzymes present in the liver are used as marker for hepatic function, Gamma-glutamyl transpeptidase (GGT), alkaline phosphatase (AP) and alanine transaminase (ALT). |
=== Aim === | === Aim === | ||
| − | We will try to find genetic determinants of the ALT and AP levels | + | We will try to find genetic determinants of the GGT, ALT and AP levels |
=== Materials and Methods === | === Materials and Methods === | ||
| Line 17: | Line 17: | ||
=== Biological or Medical aspects === | === Biological or Medical aspects === | ||
| − | The genetics underlying changes in | + | The genetics underlying changes in liver enzymes levels is not enterily known and finding new determinants (genes, regulatory elements...) will help to undersrand the physiology behind. |
=== Supervisor === | === Supervisor === | ||
Tanguy Corre | Tanguy Corre | ||
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| + | |||
| + | |||
| + | === Student's Project 2016=== | ||
| + | You can access our project on this page [http://www2.unil.ch/cbg/index.php?title=User:Sbprm2016_8] | ||
Latest revision as of 21:46, 9 June 2016
Contents
Background
The liver is a vital organ in the abdomen. It harbors a wide range of functions, from metabolites detoxification to secretion of digestive biochemicals. Three enzymes present in the liver are used as marker for hepatic function, Gamma-glutamyl transpeptidase (GGT), alkaline phosphatase (AP) and alanine transaminase (ALT).
Aim
We will try to find genetic determinants of the GGT, ALT and AP levels
Materials and Methods
We will perform and analyse multiple association tests between millions of SNPs throughout the genome and the phenotypes measured in the COLAUS population, a population based study from the Lausanne area comprising more than 5000 individuals. Such approach is called Genome-Wide Association Study (GWAS).
Mathematical Tools
Linear regressions, multiple testing corrections
Biological or Medical aspects
The genetics underlying changes in liver enzymes levels is not enterily known and finding new determinants (genes, regulatory elements...) will help to undersrand the physiology behind.
Supervisor
Tanguy Corre
Student's Project 2016
You can access our project on this page [1]
