Difference between revisions of "Control of mitosis in fission yeast"
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'''Mathematical tools''': Ordinary differential equations, Mathematica, Matlab | '''Mathematical tools''': Ordinary differential equations, Mathematica, Matlab | ||
| − | '''Biological or Medical aspects''': Pom1 is a protein | + | '''Biological or Medical aspects''': Pom1 is a protein which forms a cortical intracellular gradient that permits to control the entry of mitosis of the fission yeast, S. Pombe. The fact is, interaction of pom1 and cdr2 induces a cell cycle delay following to a gene activation cascade. |
Microtubuls performs | Microtubuls performs | ||
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#hachet10 pmid=21703453 | #hachet10 pmid=21703453 | ||
#Tatata pmid=21703453 | #Tatata pmid=21703453 | ||
| + | #CSHperspectives pmid=2773637 | ||
</biblio> | </biblio> | ||
| − | |||
Revision as of 10:08, 11 May 2012
Background: Fission yeast cells growth up to a given size and then enters mitosis. The question this project addresses is how does the cell knows it has reached to right size for division. This is achieved by a gradient of the pom1 protein along the cortex.
Goal: The goal is to mathematically describe the mechanism by which such a gradient is achieved using differential equation and analyze such gradients from fluorescence microscopy images.
Mathematical tools: Ordinary differential equations, Mathematica, Matlab
Biological or Medical aspects: Pom1 is a protein which forms a cortical intracellular gradient that permits to control the entry of mitosis of the fission yeast, S. Pombe. The fact is, interaction of pom1 and cdr2 induces a cell cycle delay following to a gene activation cascade. Microtubuls performs
Supervisor: Sascha Dalessi
Students: Degrugillier Lucas, Delapierre Fabien, Merçay Johan.
Presentation:
Final Report:
References:
<biblio>
- hachet10 pmid=21703453
- Tatata pmid=21703453
- CSHperspectives pmid=2773637
</biblio>
Back to UNIL BSc course: "Solving Biological Problems that require Math 2012"]
