Control of mitosis in fission yeast

Background: Fission yeast cells growth up to a given size and then enters mitosis. The question this project addresses is how does the cell knows it has reached to right size for division. This is achieved by a gradient of the pom1 protein along the cortex.

Goal: The goal is to mathematically describe the mechanism by which such a gradient is achieved using differential equation and analyze such gradients from fluorescence microscopy images.

Mathematical tools: Ordinary differential equations, Mathematica, Matlab

Biological or Medical aspects: Pom1 is a protein which forms a cortical intracellular gradient that permits to control the entry of mitosis of the fission yeast, S. Pombe. The fact is, interaction of pom1 and cdr2 induces a cell cycle delay following to a gene activation cascade. Microtubuls performs

Supervisor: Sascha Dalessi

Students: Degrugillier Lucas, Delapierre Fabien, Merçay Johan.

Presentation:

Final Report:

References: <biblio>

1. hachet10 pmid=21703453
2. Tatata pmid=21703453
3. CSH pmid=2773637

</biblio>

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