ISA

Large sets of data, like expression profile from many samples, require analytic tools to reduce their complexity. The Iterative Signature Algorithm (ISA) was designed to reduce the complexity of very large sets of data by decomposing it into so-called "modules". In the context of gene expression data these modules consist of subsets of genes that exhibit a coherent expression profile only over a subset of microarray experiments. Genes and arrays may be attributed to multiple modules and the level of required coherence can be varied resulting in different "resolutions" of the modular mapping. Since the ISA does not rely on the computation of correlation matrices (like many other tools), it is extremely fast even for very large datasets.

Software for Gene expression data

We developed the eisa GNU R package to facilitate the modular analysis of gene expression data. The package uses standard BioConductor data structures and includes various visualization tools as well.

Requirements, download and installation

To use eisa you will need a working GNU R installation.

As of the 23rd of April, 2010, the eisa package is an official BioConductor package.

eisa depends on a number of other R packages: isa2, Biobase, AnnotationDbi, Category, genefilter, DBI. The good news is that all these dependencies are installed automatically, and all you need to do is to start R and type in

 source("http://bioconductor.org/biocLite.R")
 biocLite("eisa")

at your R prompt. See the eisa package page at the BioConductor website for details.

Alternatively, you can also download the package from here:

• Microsoft Windows (32 bit)
  Download this file, save it in a temporary directory, and then start R. From the Packages menu choose 'Install packages from local zip files' and select the saved file.
• Microsoft Windows (64 bit)
  Download this file, save it in a temporary directory, and then start R. From the Packages menu choose 'Install packages from local zip files' and select the saved file.
• Mac OSX (Leopard)
  Download and install this file.
• Linux and Unix systems, R source package
  Download this file, save it in a temporary directory, and start R. Install the downloaded package using the install.packages() function: give the full path of the saved file and use the 'repos=NULL' argument of install.packages().

License

The eisa package is licensed under the GNU General Public License, version 2 or later. For details, see http://www.gnu.org/licenses/old-licenses/gpl-2.0.html.

Software for any tabular data

The ISA can be applied to identify coherent substructures (i.e. modules) from any rectangular matrix of data. You can use the isa2 R package for such an analysis.

Requirements

No additional R package is required to install and use isa2. But on Linux and Unix systems you will need a C compiler to install it. E.g. on Ubuntu Linux you will need to install the build-essential package.

Installation

The isa2 package is available from CRAN, the standard R package repository. You can install it on any platform that is supported by GNU R, e.g. Microsoft Windows, Mac OSX and Linux systems. To install it, start R and type in

 install.packages("isa2")

at the prompt. On Linux and Unix-like systems, you will need a working C compiler for a successful installation.

License

The isa2 package is licensed under the Creative Commons Attribution-Noncommercial-Share Alike 3.0 License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ or send a letter to Creative Commons, 171 Second Street, Suite 300, San Francisco, California, 94105, USA.

Tutorials

The Iterative Signature Algorithm for Gene Expression Data

Shows the typical steps of modular analysis, from loading you expression data to the visualization of transcription modules.
HTML PDF Rnw R code

ISA and the biclust package

The biclust package implements several biclustering algorithms. It is possible to convert the results of biclust to transcription modules and vice-versa.
HTML PDF Rnw R code

Tissue specific expression with the Iterative Signature Algorithm

HTML PDF Rnw R code

Hierarchical module trees

A module tree is the hierarchical modular organization of a data set.
HTML PDF Rnw R code

The Iterative Signature Algorithm

Tutorial for the analysis of tabular data with the isa2 R package.
HTML PDF Rnw R code

Running ISA in parallel

Shows how to run ISA on a computer cluster or multi-processor machine, using MPI and the Rmpi and snow R packages.
HTML PDF Rnw R code

ISA internals

HTML PDF Rnw R code

Matlab package

You can download it from here. It also includes the implementation of the Ping-pong algorithm Kutalik2008NB. The "testPP.m" file explains how the algorithm is applied to a pair of toy data sets. To test the ISA functionalities, the "testISA.m" needs to be launched.

Papers

Grutman AJ, Perelmuter S, Perez A, Meurer J, Contractor M, Mathews E, Shearer K, Burnett LA, Uloko M
Understanding Patient Experiences of Vulvodynia Through Reddit: Qualitative Analysis.
JMIR Infodemiology: 2025 Mar 6, 5;e63072
[PubMed:40048638] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Muscat DM, Hinton R, Kuruvilla S, Nutbeam D
"Your Life, Your Health: Tips and Information for Health and Well-Being": Development of a World Health Organization Digital Resource to Support Universal Access to Trustworthy Health Information.
JMIR Form Res: 2025 Mar 6, 9;e57881
[PubMed:40048561] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Ali MS
Multilevel analysis of undergoing clinical breast examination and its associated factors among mothers of reproductive age in Kenya: Kenyan Demographic and Health Survey 2022.
PLoS One: 2025, 20(3);e0319183
[PubMed:40048484] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Van Yper L, Brandt C, Korsholm M, Godballe C, Schmidt JH, Neher T
The Impact of Early Childhood Otitis Media on Hearing Abilities: A Scoping Review.
Ear Hear: 2025 Mar 5;
[PubMed:40048374] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

An D, Kang L, Xu K
Real-Time Neural Homogeneous Translucent Material Rendering Using Diffusion Blocks.
IEEE Trans Vis Comput Graph: 2025 Mar 6, PP;
[PubMed:40048337] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Bucur AM, Moldovan AC, Parvatikar K, Zampieri M, KhudaBukhsh AR, Dinu LP
On the State of NLP Approaches to Modeling Depression in Social Media: A Post-COVID-19 Outlook.
IEEE J Biomed Health Inform: 2025 Mar 6, PP;
[PubMed:40048334] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Kari FA, Michel S, Alalawi Z, Hörer J
Repair of aorto-left ventricular tunnel type IV with origin above the left main coronary artery.
Multimed Man Cardiothorac Surg: 2025 Mar 6, 2025;
[PubMed:40048233] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Nassani MZ, Alsalhani A, Alali FM, Rastam S, Alqhtani NR, Alqahtahni AS, Robaian A, Alhedyan FS, Bin Nabhan A, Alenazi A, Alqahtani KA, Alrafedah A, Abbas Alleft AA, Alnufaiy B, Alshenaiber R, Alghabban RO, Alagla M, Abuelqomsan MAS, Al-Joukhadar M, Al Zahed N, Darwish S, Sioufi A, Shamsy E, Kujan O, Noushad M, Al-Maweri SA, Binrayes A, Sabbagh B, Tarakji B
Public Awareness and Knowledge of Oral Cancer in 13 Middle Eastern and North African Countries.
JAMA Netw Open: 2025 Mar 3, 8(3);e250522
[PubMed:40048163] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Hamp N, Radesky J, Weeks HM, Miller AL, Kaciroti N
Novel Profiles of Family Media Use: Latent Profile Analysis.
JMIR Pediatr Parent: 2025 Mar 6, 8;e59215
[PubMed:40048153] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Govindaraj V, Anandan DK, Kim SK, Raval R, Raval K
Process optimisation for improved chitinase production from marine isolate Bacillus haynesii and bioethanol production with Saccharomyces cerevisiae.
Braz J Microbiol: 2025 Mar 6;
[PubMed:40048141] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

You Z, Wang Y, Xiao Y
Analysing the Suitability of Artificial Intelligence in Healthcare and the Role of AI Governance.
Health Care Anal: 2025 Mar 6;
[PubMed:40048068] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Alnaqbi KA, Alaswad M, Alasfour S
Patient perspectives on rheumatic and musculoskeletal diseases: insights from a large-scale survey.
Clin Rheumatol: 2025 Mar 6;
[PubMed:40047988] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Karila L, Scher N, Draghi C, Lichte D, Darmon I, Boudabous H, Lamallem H, Bauduceau O, Bollet M, Toledano A
Understanding Problematic Smartphone and Social Media Use Among Adults in France: Cross-Sectional Survey Study.
JMIR Ment Health: 2025 Mar 6, 12;e63431
[PubMed:40047899] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

DuPont-Reyes MJ, Zou W, Li J, Villatoro AP, Tang L
A machine learning language model approach to evaluating mental health awareness content across Spanish- and English-language social media posts on Twitter.
Soc Psychiatry Psychiatr Epidemiol: 2025 Mar 6;
[PubMed:40047852] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Shah T, Polara H, Babanyinah G, Bhadran A, Wang H, Castillo CC, Grabowski G, Biewer MC, Torabifard H, Stefan MC
Computational design to experimental validation: molecular dynamics-assisted development of polycaprolactone micelles for drug delivery.
J Mater Chem B: 2025 Mar 6;
[PubMed:40047718] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Qiu Y, Chen A, Yu R, Llevenes P, Seen M, Ko NY, Monti S, Denis GV
Insulin Resistance Increases TNBC Aggressiveness and Brain Metastasis via Adipocyte-derived Exosomes.
Mol Cancer Res: 2025 Mar 6;
[PubMed:40047645] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Senchikhin IN, Konarev PV, Volkov VV, Trigub AL, Zhavoronok ES
Structure and supramolecular organization of silver nitrate modified epoxy or amino terminated liquid oligoethers.
J Chem Phys: 2025 Mar 7, 162(9);
[PubMed:40047518] [WorldCat.org: ISSN ESSN ] [DOI] ( p)

Brigodiot C, Speirs E, Guyon C, Tatoulian M, Pannacci N
Fabrication of COC micromodels with wettability heterogeneities: method and influence on fluid transport.
Soft Matter: 2025 Mar 6;
[PubMed:40047489] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

McCullough HC, Song H-S, Auchtung JM
Diversity in chemical subunits and linkages: a key molecular determinant of microbial richness, microbiota interactions, and substrate utilization.
Microbiol Spectr: 2025 Mar 6;e0261824
[PubMed:40047463] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Layton AM, McCauley C, Redding KE
Deletion of Re-citrate synthase allows for analysis of contributions of tricarboxylic acid cycle directionality to the growth of Heliomicrobium modesticaldum.
Appl Environ Microbiol: 2025 Mar 6;e0177224
[PubMed:40047422] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Raju S, M D, H B, S M, Krishnappa M, Kumar S, Marappa S
A step towards efficient water splitting: a high-performance CuCo(OH)(2)/CNT/MoS(2) electrocatalyst.
Nanoscale: 2025 Mar 6;
[PubMed:40047378] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Yahyazadeh Shourabi A, Iacona M, Aubin-Tam ME
Microfluidic system for efficient molecular delivery to artificial cell membranes.
Lab Chip: 2025 Mar 6;
[PubMed:40047333] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Wang Y, Sanyal AJ, Hylemon P, Ren S
Discovery of A Novel Regulator, 3β-Sulfate-5-Cholestenoic Acid, of Lipid Metabolism and Inflammation.
Am J Physiol Endocrinol Metab: 2025 Mar 6;
[PubMed:40047198] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Moshe T, Rudyk I, Magnezi R
Engaging blood donors as advocates: Social media preferences and associations with marketing stimuli.
Transfusion: 2025 Mar 6;
[PubMed:40047192] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Topsakal HNH, Asarkaya MC, Akcan E, Çifçi M, Karaman R, Doğan S, Çelik EN, Bakir B, Günter Y, Aydoğan O
Microbial Art Fixation on Agar Plate: MicArt Fixation for Microbiology Teaching.
J Basic Microbiol: 2025 Mar 6;e70018
[PubMed:40047174] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Spary-Kainz U, Posch N, Siebenhofer A, Ožvačić Adžić Z, Zelko E
Exploring awareness and perceptions of palliative care: a descriptive cross-sectional survey study in Central Europe.
Croat Med J: 2025 Feb 28, 66(1);27-34
[PubMed:40047159] [WorldCat.org: ISSN ESSN ] ( p)

Billinson J
"Smash That Follow Button": Leadership Development With TikTok.
New Dir Stud Leadersh: 2025 Mar 6;
[PubMed:40047095] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Belala R, Medjkoune M, Aiche A, Mimoune N
Effect of Dilution Media and Incubation Time on Motility, Kinetic and Morphometric Parameters of Canine Spermatozoa Using CASA System.
Reprod Domest Anim: 2025 Mar, 60(3);e70030
[PubMed:40047045] [WorldCat.org: ISSN ESSN ] [DOI] ( p)

Fretes G, Veliz P, Narvaez AM, Williams D, Sibille R, Arts M, Leroy JL
Digital Marketing of Unhealthy Foods and Non-alcoholic Beverages to Children and Adolescents: A Narrative Review.
Curr Dev Nutr: 2025 Feb, 9(2);104545
[PubMed:40046995] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Nishimura T, Hosoi H, Saito O, Shimokura R, Okayasu T, Morimoto C, Kitahara T
The Effect of Gel Application on the Transducer in Cartilage Conduction Hearing Aids: A Case Series Study.
Laryngoscope Investig Otolaryngol: 2025 Apr, 10(2);e70108
[PubMed:40046981] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Fareed FFI, Uthayanan L, Anderson R, Kotecha S, Mazzoleni A, Erhabor J, Kumar NS, Wong W
Bridging gaps in global surgery: Insights from an international hybrid conference.
Surg Open Sci: 2025 Mar, 24;38-41
[PubMed:40046957] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Yang L, Qin Z, Yao J, Xu H, Tian J, Ren Y, Wang H, Meng W
Enhancing patient satisfaction and reducing nurse workload: the impact of multimedia health education in a prospective single-center randomized controlled trial.
Front Med (Lausanne): 2025, 12;1400061
[PubMed:40046935] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Krejcar O, Namazi H
Multiscale brain modeling: bridging microscopic and macroscopic brain dynamics for clinical and technological applications.
Front Cell Neurosci: 2025, 19;1537462
[PubMed:40046848] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Hanny D, Arifi D, Knoblauch S, Resch B, Lautenbach S, Zipf A, de Aragão Rocha AA
An explainable GeoAI approach for the multimodal analysis of urban human dynamics: a case study for the COVID-19 pandemic in Rio de Janeiro.
Comput Urban Sci: 2025, 5(1);13
[PubMed:40046777] [WorldCat.org: ISSN ESSN ] [DOI] ( o)

Garg M, Sathvik M, Raza S, Chadha A, Sohn S
Reliability Analysis of Psychological Concept Extraction and Classification in User-penned Text.
Proc Int AAAI Conf Weblogs Soc Media: 2024 May 31, 18;422-434
[PubMed:40046688] [WorldCat.org: ISSN ESSN ] [DOI] ( o)

Bielby J, Austen G, McMillan K, Wafflart S
Exploring media representation of the exotic pet trade, with a focus on welfare: taxonomic, framing and language biases in peer-reviewed publications and newspaper articles.
R Soc Open Sci: 2025 Mar, 12(3);240952
[PubMed:40046661] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Klett A, Raith D, Silvestrini P, Stingl M, Bermeitinger J, Sapre A, Condor M, Melachrinos R, Kusterer M, Brand A, Pisani G, Ullrich E, Follo M, Duque-Afonso J, Mertelsmann R
Leveraging automated time-lapse microscopy coupled with deep learning to automate colony forming assay.
Front Oncol: 2025, 15;1520972
[PubMed:40046624] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Putri BBK, Noer AH, Purba FD
Psychological Factors Influencing Appearance Anxiety Among Adolescents: A Systematic Literature Review.
Psychol Res Behav Manag: 2025, 18;487-503
[PubMed:40046607] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Li H, Li Y, Wang J, Zhang Y, Ben S
Enablers and Barriers to Medication Self-Management in Patients With Type 2 Diabetes: A Qualitative Study Using the COM-B Model.
Patient Prefer Adherence: 2025, 19;485-501
[PubMed:40046565] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Busse M, Pallmann P, Riaz M, Potter C, Leggat FJ, Harris S, Longman AJ, Lowe R, Edwards A, Siriwardena AN, Sevdalis N, McRae J, Fish J, Sewell B, Jones F
Effectiveness of a personalised self-management intervention for people living with long covid (Listen trial): pragmatic, multicentre, parallel group, randomised controlled trial.
BMJ Med: 2025 Jan, 4(1);e001068
[PubMed:40046291] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Lopes B, Sousa AC, Sousa P, de Sousa Moreira A, Coelho AF, Atayde L, Salgado AJ, Geuna S, Alvites R, Maurício AC
In vitro evaluation of dental pulp stem cells for sciatic nerve regeneration: foundations for future in vivo applications.
Front Cell Dev Biol: 2025, 13;1528213
[PubMed:40046233] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Napolitano F, Giudice V, D'Esposito V, Prevete N, Scala P, de Paulis A, Selleri C, Formisano P, Rossi FW, Montuori N
Cell-free regenerative medicine: identifying the best source of mesenchymal stem cells for skin therapy in Systemic Sclerosis.
Front Cell Dev Biol: 2025, 13;1518412
[PubMed:40046231] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Umut İ, Köse S
The Relationship Between Autistic Traits, Internet Addiction, Perceived Social Support and Life Satisfaction.
Noro Psikiyatr Ars: 2025, 62(1);34-40
[PubMed:40046204] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Völker F, Hoffmann K, Halmschlag B, Maaß S, Büchs J, Blank LM
Citrate Supplementation Modulates Medium Viscosity and Poly-γ-Glutamic Acid Synthesis by Engineered B. subtilis 168.
Eng Life Sci: 2025 Mar, 25(3);e70009
[PubMed:40046170] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Yanagi M
Cavitary Pulmonary Disease Caused by Mycobacterium kyorinense: A Case Report on a 3-Year Clinical Course.
Respirol Case Rep: 2025 Mar, 13(3);e70142
[PubMed:40046168] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Li Y, Li J, Lu C
Explore factors influencing residents' green lifestyle: evidence from the Chinese General Social Survey data.
Front Public Health: 2025, 13;1527247
[PubMed:40046119] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Merrill KG, Fuentes J, Merrill J, DeCelles J, Silva J, Sedeño A, Salgado S, Vargas S, Cano JK, Nabor V, Rodriguez L, Melgoza V, Mora C, Baumann AA, Guastaferro K, Donenberg GR
Adapting a sexual and reproductive health program for Latina teens and their female caregivers: a qualitative study.
Front Public Health: 2025, 13;1501757
[PubMed:40046110] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Maher C, Gaffiero D
Exploring the lived experiences of patients with fibromyalgia in the United Kingdom: a study of patient-general practitioner communication.
Psychol Health: 2025 Mar 6;1-22
[PubMed:40045872] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Chowdhury N, Rabel EJ, Ferraz D, Del Rio Carral M
Between being affected and being an active emotion 'manager': young women's accounts of social media use and wellbeing.
Psychol Health: 2025 Mar 5;1-21
[PubMed:40045473] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Luz PM, Torres TS, Matos VC, Costa GG, Hoagland B, Pimenta C, Benedetti M, Grinsztejn B, Veloso VG
Socio-economic status and adherence to HIV preventive and therapeutic interventions: exploring the mediating role of food insecurity among men who have sex with men and transgender and non-binary persons from Brazil.
J Int AIDS Soc: 2025 Mar, 28(3);e26432
[PubMed:40045441] [WorldCat.org: ISSN ESSN ] [DOI] ( p)

Rizwan A, Sridharan B, Park JH, Kim D, Vial JC, Kyhm K, Lim HG
Nanophotonic-enhanced photoacoustic imaging for brain tumor detection.
J Nanobiotechnology: 2025 Mar 5, 23(1);170
[PubMed:40045308] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Galvez-Hernandez P, Dai Y, Muntaner C
The DANA disaster: unraveling the political and economic determinants for Valencia's floods devastation.
Int J Equity Health: 2025 Mar 5, 24(1);64
[PubMed:40045305] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Borojevic V, Söhner F
Detecting and understanding potential stigma among medical cannabis users in Germany.
BMC Public Health: 2025 Mar 5, 25(1);874
[PubMed:40045288] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Agbavor B, Arthur RA, Agbanyo A, Ahiatrogah DK, Akenten CW, Adu-Asiamah C, Abass KM, Ofori E, Amofa G, Boampong K, Thye T, Dekker D, Addo MG, Wansbrough-Jones M, Bull TJ, Amoako YA, Phillips RO
Improved protocols for isolation of Mycobacterium ulcerans from clinical samples.
BMC Microbiol: 2025 Mar 5, 25(1);118
[PubMed:40045245] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

de Oliveira Guardalini LG, Moura Dias F, Omae Camalhonte S, Leme J, Consoni Bernardino T, Soares Sposito F, Dias E, Mancini Astray R, Tonso A, Attie Calil Jorge S, Fernández Núñez EG
Multiplicity of infection and culture medium on the SARS-CoV-2 virus like-particles production by baculovirus/insect system.
Biotechnol Lett: 2025 Mar 6, 47(2);32
[PubMed:40045076] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Movahed ZG, Mansouri K, Mohsen AH, Matin MM
Bone marrow mesenchymal stem cells enrich breast cancer stem cell population via targeting metabolic pathways.
Med Oncol: 2025 Mar 5, 42(4);90
[PubMed:40045066] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Liu L, Ma B
CA-VAR-Markov model of user needs prediction based on user generated content.
Sci Rep: 2025 Mar 5, 15(1);7716
[PubMed:40044745] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Wang J
Using Masao facial makeup in software interface interaction design from the perspective of digital communication.
Sci Rep: 2025 Mar 5, 15(1);7680
[PubMed:40044739] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Matsuzaki T, Kosugi K, Iwami H, Kambe T, Kiuchi H, Harada Y, Asakura D, Uematsu T, Kuwabata S, Saga Y, Kondo M, Masaoka S
Iron-complex-based catalytic system for high-performance water oxidation in aqueous media.
Nat Commun: 2025 Mar 5, 16(1);2145
[PubMed:40044652] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Cho S, Choi SH, Maeng E, Park H, Ryu KS, Park KS
Boosting tumor homing of endogenous natural killer cells via therapeutic secretomes of chemically primed natural killer cells.
J Immunother Cancer: 2025 Mar 5, 13(3);
[PubMed:40044578] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Tang WHW
Targeting Inflammation in Heart Failure Prevention: Are There Sex Differences?
JACC Heart Fail: 2025 Mar, 13(3);450-452
[PubMed:40044381] [WorldCat.org: ISSN ESSN ] [DOI] ( p)

Wieneke KC, Berkland BE, Kruse GC, Priestley MR, Teal DM, West CP
Charting a New Path Forward in Addressing Employee Well-being in Health Care.
Mayo Clin Proc: 2025 Mar, 100(3);501-513
[PubMed:40044362] [WorldCat.org: ISSN ESSN ] [DOI] ( p)

Bunch PM, Rigdon J, Lenchik L, Gorris MA, Randle RW
Potential Impact of Opportunistic CT for Closing Diagnosis Gaps in Primary Hyperparathyroidism.
J Am Coll Radiol: 2025 Mar, 22(3);376-385
[PubMed:40044317] [WorldCat.org: ISSN ESSN ] [DOI] ( p)

Taccardi D, Gowdy HGM, Li VW, Wing AC, Baharnoori M, Finlayson M, Ghasemlou N
Circadian rhythmicity of symptomatic phenotypes in multiple sclerosis: the CircaMS study protocol and feasibility of biomarker collection.
BMJ Open: 2025 Mar 5, 15(3);e095357
[PubMed:40044201] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Yamaguchi K, Ichinohe K, Iyadomi M, Fujiki K, Yoshinaga Y, Egashira R, Nakazono T
Abbreviated and Ultrafast Dynamic Contrast-enhanced (DCE) MR Imaging.
Magn Reson Med Sci: 2025 Mar 5;
[PubMed:40044152] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Wang Z, Benicky J, Mukherjee P, Laing J, Xu Y, Pagadala V, Wu S, Hippensteel JA, Goldman R, Liu J
Development of a method to measure the activity of heparan sulfate 6-endosulfatase for biological research.
Glycobiology: 2025 Mar 5;
[PubMed:40044126] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Adamczyk PA, Hwang HJ, Chang TH, Gao Y, Baidoo EEK, Kim J, Webb-Robertson BM, Flores JE, Quijano KC, Burnet MC, Munoz N, Sundstrom E, Gladden JM, Liu D
The oleaginous yeast Rhodosporidium toruloides engineered for biomass hydrolysate-derived (E)-⍺-bisabolene production.
Metab Eng: 2025 Mar 3;
[PubMed:40044027] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Antara NH, Stephan D
Chitin-amended media: Improving efficacy of Cordyceps fumosorosea as a control agent of Cydia pomonella.
J Invertebr Pathol: 2025 Mar 3;108296
[PubMed:40043903] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Favaro L, Casella S, Parro E, Franzosi G, Rodighiero V, Basaglia M
Utilization of lactose and whey permeate for the sustainable production of polyhydroxyalkanoates by Hydrogenophaga pseudoflava DSM1034.
N Biotechnol: 2025 Mar 3;
[PubMed:40043839] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Kodur N, Nguyen C, Tang WHW
Therapeutic Ketosis for Heart Failure: A State-of-the-Art-Review.
J Card Fail: 2025 Mar 3;
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Strohmayer NJ, Camarillo IA, Choi H, Ottman R
Information on epilepsy genetics available online for people with epilepsy and their families.
Epilepsy Behav: 2025 Mar 4, 166;110361
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Tremblay N, Lavoie KL, Bacon SL, Bélanger-Gravel A, iCARE Study Team
Unveiling the association between information sources and young adults' attitudes and concerns during COVID-19: Results from the iCARE study.
Public Health: 2025 Mar 4, 242;87-93
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Clark KD, Bosse JD, Jackman KB, Brown D, Dubay J, Jewell J, Flanders S, Hardwick C, Dawson-Rose C
"I don't think I have been out of fight or flight. Ever." transgender people's experiences in inpatient psychiatric treatment.
Int J Nurs Stud: 2025 Feb 12, 165;105028
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Chen Z, Wang B, Farooq U, Lu T, Qi Z, Zhang L, Miao R
pH-dependent transport of tetracycline in saturated porous media: Single and combined effects of surfactants and iron oxide colloids.
J Hazard Mater: 2025 Mar 3, 490;137829
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Tao D, Xie C, Jaffrezic-Renault N, Guo Z
Flexible and wearable electrochemical sensors for health and safety monitoring.
Talanta: 2025 Feb 28, 291;127863
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Anderson K, Looi JC, Allison S, Bastiampillai T, Kisely S, Maguire PA, Woon L
Stopping antidepressants or not?
Aust J Gen Pract: 2025 Mar, 54(3);91-94
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A Okoye G, Bui H, Zadu A, A Myles I, S Byrd A
The Multifaceted Effects of Berberine: Potential Uses in Dermatology.
J Drugs Dermatol: 2025 Mar 1, 24(3);298-301
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Ezzat R, Maskan Bermudez N, Tosti A
Social Media's Impact on Hair Loss Information Dissemination: A Systematic Review.
J Drugs Dermatol: 2025 Mar 1, 24(3);307-311
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Yang F
Selling female pleasure: women's adult industry and its podcasting in mainland China.
Cult Health Sex: 2025 Mar 5;1-16
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Harell A, Foroutan Y, Ahuja N, Datta P, Kanzariya B, Somayazulu VS, Tickoo O, de Andrade A, Bajic IV
Rate-Distortion Theory in Coding for Machines and its Applications.
IEEE Trans Pattern Anal Mach Intell: 2025 Mar 5, PP;
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Gielas AM
Man, Hibernating Animals, and Poikilothermic: Fish The Present and Future of BCI Technology.
J Spec Oper Med: 2025 Mar 5;
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Gómez-Restrepo C, Diez-Canseco F, Brusco LI, Jassir Acosta MP, Olivar N, Carbonetti FL, Hidalgo-Padilla L, Toyama M, Uribe-Restrepo JM, Rodríguez Malagon N, Niño-Torres D, Godoy Casasbuenas N, Stanislaus Sureshkumar D, Fung C, Bird V, Morgan C, Araya R, Kirkbride J, Priebe S
Mental Distress Among Youths in Low-Income Urban Areas in South America.
JAMA Netw Open: 2025 Mar 3, 8(3);e250122
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Mu W, Sun H, Cao L
Water absorption dynamics in medical foam: empirical validation of the Lucas-Washburn model.
Eur Phys J E Soft Matter: 2025 Mar 5, 48(3);13
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Chen K, Sundaram S, Lo DF, Gawash A, Papachristou C, Raja AE
Scaling new heights: a prospective survey of rock climbing's impact on mental health.
Discov Ment Health: 2025 Mar 5, 5(1);29
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Ma B, Rose J, Rojas EM, Castro-Núñez J
Is oral and maxillofacial surgery lagging behind other specialties on X?
Oral Maxillofac Surg: 2025 Mar 5, 29(1);61
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Komati N, Riboli E, Dore J, Boyland E, Cravedi JP, Folkvord F, Lecerf JM, Lescourret F, Peeters A, Reynolds C, Alles B, Amiot MJ, Binard P, Delzenne N, Forouhi N, Giner C, Giyose B, Gonzalez CG, Gunter MJ, Kahane R, Herforth A, Hermans R, Intrigliolo DS, Montanaro G, Neri D, Nicklaus S, Santacoloma P, Sauvaitre D, Selosse MA, Smits T, Stranges S, Thivel D, Toledo PC, Van Lieshout M, Verschuren WMM, Wickramasinghe K, Zeinstra G, Chambrier C, Calvarin J, Tailliez D
Diet, fruit and vegetables and One Health: benefits for health, environment, society and the consumer-proceedings of the 9th edition of EGEA conference.
Eur J Nutr: 2025 Mar 5, 64(3);108
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Kustritz MVR, Ondrey J
Comparison of Student Satisfaction and Ease of Grading When Completing Cases Using Basic or Enhanced Case Study Formats.
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Srikajornlarp S, Lerksuthirat T, Patpong P, Ongphiphadhanakul B, Chattaris T
Exploring public perceptions of dementia on Twitter (X): a cross-cultural analysis.
Alzheimers Dement: 2025 Mar, 21(3);e70042
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Volgenant CMC, Hesse D
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Ned Tijdschr Tandheelkd: 2025 Mar 4, 132(3);145-147
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Holtmann FJ, Lalk C, Rubel J, Vocks S
Assessing the Impact of a Reality TV Fashion Model Contest on Women's State Body Dissatisfaction, Affect, and Self-Esteem: An Experience Sampling Study of Women With and Without Eating Disorders.
Eur Eat Disord Rev: 2025 Mar 5;
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Kavaliunaite E, Andersen TE, Lindholt JS, Stubbe J
Daily fenugreek intake does not attenuate abdominal aortic aneurysm growth in rats.
Vasa: 2025 Mar 5;
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Eraslan-Sakar A, Yalcin OK, Mazi A, Yildiz C
The Effects of Supplemented Coenzyme Q(10) to Extender on the Endoplasmic Reticulum Stress-Related Genes and Sperm Quality Parameters in Cryopreservation of Mouse Spermatozoa.
Biopreserv Biobank: 2025 Mar 5;
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Bong SH, Choi H, Song HH, Kim DK, Mook-Jung I, Lee DY
Metabolic Reprogramming in Primary Microglial Cell and Extracellular Vesicle Triggered by Aβ Exposure.
J Neurochem: 2025 Mar, 169(3);e70030
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Patterson-Stephens S, Beatty C, Smith F
Creating to Transgress: Supporting Student Leadership Development Through Culturally Informed Media Praxis.
New Dir Stud Leadersh: 2025 Mar 5;
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Liu S, Cao D, Han X, Hou A, Wang S, Yan X
Degradable Polymer-Fueled Artificial Colloidal Motors.
Macromol Rapid Commun: 2025 Mar 5;e2401018
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Gutiérrez-Zúñiga D, Candura D, Delgado C, Calvo E
Latarjet and Bankart Repairs: Instagram-Based Perception Analysis Shows Comparable Patient Experiences.
Arthrosc Sports Med Rehabil: 2025 Feb, 7(1);101020
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Cesarek MR, Gerard NO 3rd, Griswold BN, Rumps MV, O'Brien MJ, Savoie FH 3rd, Mulcahey MK
Forty-Two Percent of Patients Undergoing Arthroscopic Shoulder Surgery Are Using Psychotropic Medications.
Arthrosc Sports Med Rehabil: 2025 Feb, 7(1);101030
[PubMed:40041838] [WorldCat.org: ISSN ESSN ] [DOI] ( )

D'Ambrosi R, Carrozzo A, Annibaldi A, Vieira TD, An JS, Freychet B, Sonnery-Cottet B
YouTube Videos Provide Low-Quality Educational Content About the Anterolateral Ligament of the Knee.
Arthrosc Sports Med Rehabil: 2025 Feb, 7(1);101002
[PubMed:40041830] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Jamil S, Hossain MJ, Mohammad Ali H, Akon MR, Asumah MN, Hasan M, Suresh H, Okesanya OJ, Al-Mamun M, Ahmed MM, Sarkar TY, Sarker MFH
Association of Knowledge and Attitude Toward Antibiotic Use and Resistance With Self-Medication Practice of Antibiotics Among Bangladeshi Private University Teachers: A Cross-Sectional Study.
Health Sci Rep: 2025 Mar, 8(3);e70526
[PubMed:40041790] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Karamchandani BM, Maurya PA, Pawar AA, Pable A, Awale M, Dalvi SG, Banat IM, Satpute SK
The role of statistical methods in optimizing and enhancing fungal chitosan commercial production.
3 Biotech: 2025 Mar, 15(3);70
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Ihmels JH, Bergmann S
Challenges and prospects in the analysis of large-scale gene expression data.
Brief Bioinform: 2004 Dec, 5(4);313-27
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Ihmels J, Bergmann S, Barkai N
Defining transcription modules using large-scale gene expression data.
Bioinformatics: 2004 Sep 1, 20(13);1993-2003
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Bergmann S, Ihmels J, Barkai N
Similarities and differences in genome-wide expression data of six organisms.
PLoS Biol: 2004 Jan, 2(1);E9
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Bergmann S, Ihmels J, Barkai N
Iterative signature algorithm for the analysis of large-scale gene expression data.
Phys Rev E Stat Nonlin Soft Matter Phys: 2003 Mar, 67(3 Pt 1);031902
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Ihmels J, Friedlander G, Bergmann S, Sarig O, Ziv Y, Barkai N
Revealing modular organization in the yeast transcriptional network.
Nat Genet: 2002 Aug, 31(4);370-7
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