ISA

Large sets of data, like expression profile from many samples, require analytic tools to reduce their complexity. The Iterative Signature Algorithm (ISA) was designed to reduce the complexity of very large sets of data by decomposing it into so-called "modules". In the context of gene expression data these modules consist of subsets of genes that exhibit a coherent expression profile only over a subset of microarray experiments. Genes and arrays may be attributed to multiple modules and the level of required coherence can be varied resulting in different "resolutions" of the modular mapping. Since the ISA does not rely on the computation of correlation matrices (like many other tools), it is extremely fast even for very large datasets.

Software for Gene expression data

We developed the eisa GNU R package to facilitate the modular analysis of gene expression data. The package uses standard BioConductor data structures and includes various visualization tools as well.

Requirements, download and installation

To use eisa you will need a working GNU R installation.

As of the 23rd of April, 2010, the eisa package is an official BioConductor package.

eisa depends on a number of other R packages: isa2, Biobase, AnnotationDbi, Category, genefilter, DBI. The good news is that all these dependencies are installed automatically, and all you need to do is to start R and type in

 source("http://bioconductor.org/biocLite.R")
 biocLite("eisa")

at your R prompt. See the eisa package page at the BioConductor website for details.

Alternatively, you can also download the package from here:

• Microsoft Windows (32 bit)
  Download this file, save it in a temporary directory, and then start R. From the Packages menu choose 'Install packages from local zip files' and select the saved file.
• Microsoft Windows (64 bit)
  Download this file, save it in a temporary directory, and then start R. From the Packages menu choose 'Install packages from local zip files' and select the saved file.
• Mac OSX (Leopard)
  Download and install this file.
• Linux and Unix systems, R source package
  Download this file, save it in a temporary directory, and start R. Install the downloaded package using the install.packages() function: give the full path of the saved file and use the 'repos=NULL' argument of install.packages().

License

The eisa package is licensed under the GNU General Public License, version 2 or later. For details, see http://www.gnu.org/licenses/old-licenses/gpl-2.0.html.

Software for any tabular data

The ISA can be applied to identify coherent substructures (i.e. modules) from any rectangular matrix of data. You can use the isa2 R package for such an analysis.

Requirements

No additional R package is required to install and use isa2. But on Linux and Unix systems you will need a C compiler to install it. E.g. on Ubuntu Linux you will need to install the build-essential package.

Installation

The isa2 package is available from CRAN, the standard R package repository. You can install it on any platform that is supported by GNU R, e.g. Microsoft Windows, Mac OSX and Linux systems. To install it, start R and type in

 install.packages("isa2")

at the prompt. On Linux and Unix-like systems, you will need a working C compiler for a successful installation.

License

The isa2 package is licensed under the Creative Commons Attribution-Noncommercial-Share Alike 3.0 License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ or send a letter to Creative Commons, 171 Second Street, Suite 300, San Francisco, California, 94105, USA.

Tutorials

The Iterative Signature Algorithm for Gene Expression Data

Shows the typical steps of modular analysis, from loading you expression data to the visualization of transcription modules.
HTML PDF Rnw R code

ISA and the biclust package

The biclust package implements several biclustering algorithms. It is possible to convert the results of biclust to transcription modules and vice-versa.
HTML PDF Rnw R code

Tissue specific expression with the Iterative Signature Algorithm

HTML PDF Rnw R code

Hierarchical module trees

A module tree is the hierarchical modular organization of a data set.
HTML PDF Rnw R code

The Iterative Signature Algorithm

Tutorial for the analysis of tabular data with the isa2 R package.
HTML PDF Rnw R code

Running ISA in parallel

Shows how to run ISA on a computer cluster or multi-processor machine, using MPI and the Rmpi and snow R packages.
HTML PDF Rnw R code

ISA internals

HTML PDF Rnw R code

Matlab package

You can download it from here. It also includes the implementation of the Ping-pong algorithm Kutalik2008NB. The "testPP.m" file explains how the algorithm is applied to a pair of toy data sets. To test the ISA functionalities, the "testISA.m" needs to be launched.

Papers

Luo M, Duan Z, Luo W, Niu Z
The increased risk of cyberbullying and its negative impact on mental health among sexual minority college students compared to their peers.
Child Adolesc Psychiatry Ment Health: 2025 Apr 2, 19(1);36
[PubMed:40176061] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Arslan N, Esin K, Ayyıldız F
A validity and reliability study of the artificial intelligence attitude scale (AIAS-4) and its relationship with social media addiction and eating behaviors in Turkish adults.
BMC Public Health: 2025 Apr 2, 25(1);1244
[PubMed:40175951] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Roberts CE, Oseni DA, Bohle-Frankel B, Reardon CL
Get your Head in the Game!: A Review of Factors that Impact Collegiate Student-Athlete Mental Health Using a Biopsychosocial-Structural Framework.
Curr Psychiatry Rep: 2025 Apr 3;
[PubMed:40175841] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Park YW, Tao X, Fisher CB
Race and Anti-Racist Online Coping as Moderators of College Adjustment Associated with Exposure to Social Media Racism among Asian, Black, and Hispanic/Latine Students.
J Youth Adolesc: 2025 Apr 2;
[PubMed:40175836] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Gao Y, He X, Deng Y, Wang X, Shen J, Xu W, Cai R, Lan X, Chen J, He Y
Human dental follicle cell-derived conditioned media enhance periodontal regeneration by regulating the osteogenic differentiation and inflammation of periodontal ligament stem cells and macrophage polarization.
Mol Cell Biochem: 2025 Apr 2;
[PubMed:40175780] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Pearson H
Do smartphones and social media really harm teens' mental health?
Nature: 2025 Apr, 640(8057);26-28
[PubMed:40175759] [WorldCat.org: ISSN ESSN ] [DOI] ( p)

Gimenes M, Lambert E, Chaussoy L, Wilson MA, Quémart P
VOC-ADO: A lexical database for French-speaking adolescents.
Behav Res Methods: 2025 Apr 2, 57(5);137
[PubMed:40175669] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Khine HEE, Suriya U, Rungrotmongkol T, Chamni S, Lu Y, Bénard A, Lan B, Mukhopadhyay D, Chang D, Biankin A, Schneider-Stock R, Grützmann R, Sungthong R, Pilarsky C, Chaotham C
Jorunnamycin A induces apoptosis in pancreatic ductal adenocarcinoma cells, spheroids, and patient-derived organoids by modulating KRAS-mediated survival pathways.
Sci Rep: 2025 Apr 3, 15(1);11376
[PubMed:40175514] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Clarkson DL, Kontar EP, Chrysaphi N, Emslie AG, Jeffrey NLS, Krupar V, Vecchio A
Tracing the heliospheric magnetic field via anisotropic radio-wave scattering.
Sci Rep: 2025 Apr 2, 15(1);11335
[PubMed:40175477] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Barber LE, Smith-Ireland D, Enun B, Johnson DA
Understanding sleep health in Black American adults: A qualitative analysis of barriers, facilitators, and perspectives on sleep interventions.
Sleep Health: 2025 Apr 1;
[PubMed:40175266] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Adhikari T, Montenegro T, Jung JW, Oare C, Fonseca G, Beaulieu L, Alshreef A, Ferreira C
The use of Monte Carlo simulation techniques in brachytherapy: A comprehensive literature review.
Brachytherapy: 2025 Apr 1;
[PubMed:40175201] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Anterasian C, Gela A, Mwambene TD, Shah JA, Ivie J, Dill-McFarland KA, Hanekom WA, Kiritsy MC, Sassetti CM, Musvosvi M, Hatherill M, Scriba TJ, Hawn TR
BCG induced innate immune response heterogeneity and susceptibility to pediatric tuberculosis.
J Immunol: 2025 Apr 2;
[PubMed:40174917] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Jiang W, Wei H, Xu Z, Kang J, Wang S, Liu D, Ren Y, Ngo HH, Guo W, Ye Y
Lighting promotes sulfate removal and improves microbial community stability in upflow anaerobic sludge bed reactors under low ratio of chemical oxygen demand to sulfate.
Bioresour Technol: 2025 Mar 31;132473
[PubMed:40174651] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Wang S, Wang H, Huang X, Wu Z, Xue H, Zhao C
A novel magnetic adsorption and capacitive deionization coupled technology for industrial saline wastewater recycling.
Water Res: 2025 Mar 26, 281;123559
[PubMed:40174564] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Suhardita K, Datuti S, Saputra R, Ramadhani E, Badriyah RUD
Strengthening suicide prevention policies in South Korea: Bridging the gap for adolescent mental health.
Asian J Psychiatr: 2025 Mar 29, 107;104472
[PubMed:40174518] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Dehaghani MST, Esfandiari Z, Khodadadi M
Application of L-leucine-based natural deep eutectic solvent and ferroferric oxide magnetic nanoparticles modified with silica and zeolitic imidazolate framework-8 (Fe(3)O(4)@SiO(2)@ZIF-8) for extracting organophosphorus pesticides from cucumber.
Food Chem: 2025 Mar 22, 481;143939
[PubMed:40174382] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Strong C, Joson P, Chu IY, Chuang TT, Wu HJ, Li CW, Huang P, Bourne A, Ku SW
Prioritization and barriers of mpox vaccination uptake among gay, bisexual and other men who have sex with men in Taiwan: 2023 HEART survey.
Vaccine: 2025 Apr 1, 53;127059
[PubMed:40174374] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Lei X, Liu B, Di C, Wei Z, Deng P, Chen Z
Molecular interactions of surfactants with other chemicals in chemical flooding processes: A comprehensive review on molecular dynamics simulation studies.
Adv Colloid Interface Sci: 2025 Mar 27, 341;103498
[PubMed:40174373] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Sackett JD, Tonucci GP, Rowe AR
Interfacial extracellular electron uptake is linked to nitrate respiration in the marine heterotroph, Thalassospira xiamenensis SN3.
Bioelectrochemistry: 2025 Mar 26, 165;108976
[PubMed:40174290] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Shahid M, Khalid S, ALOthman ZA, Al-Kahtani AA, Bibi I, Naz R, Natasha N, Niazi NK, Iqbal J, Han C, Shah NS, Murtaza B
Trace element removal from wastewater by agricultural biowastes: A data analysis on removal efficacy and optimized conditions.
Sci Total Environ: 2025 Apr 1, 975;179235
[PubMed:40174245] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Zarrillo TA, Stoner KA, Ascher JS
Biodiversity of Bees (Hymenoptera: Apoidea: Anthophila) in Connecticut (USA).
Zootaxa: 2025 Feb 12, 5586(1);1-138
[PubMed:40174048] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Wight L, Tenove C, Hirani S, Tworek H
Mental Health and Coping Strategies of Health Communicators Who Faced Online Abuse During the COVID-19 Pandemic: Mixed Methods Study.
JMIR Infodemiology: 2025 Apr 2, 5;e68483
[PubMed:40173443] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Fijany AJ, Holan CA, Bishay AE, Boctor MJ, Montorfano L, Mubang RN, Vijayasekaran A, Martinez-Jorge J, Harless CA, Thayer WP, Connor LM, Lineaweaver WC, Slater ED
Beyond the Posts: Analyzing Breast Implant Illness Discourse With Natural Language Processing and Deep Learning.
Aesthet Surg J: 2025 Apr 2;
[PubMed:40173420] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Adegboyega A, Wiggins A, Wuni A, Ickes M
The Impact of a Human Papillomavirus Facebook-Based Intervention (#HPVVaxTalks) Among Young Black (African American and Sub-Saharan African Immigrants) Adults: Pilot Pre- and Poststudy.
JMIR Form Res: 2025 Apr 2, 9;e69609
[PubMed:40173371] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Xu J, Zou Y, Chen H, Wan Z, Takagi A, Wang Z, Yu J, Liu L, Lu Y, Fan Y, Rojas OJ
Magnetoresponsive Cellulose Nanofiber Hydrogels: Dynamic Structuring, Selective Light Transmission, and Information Encoding.
ACS Nano: 2025 Apr 2;
[PubMed:40173319] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Cui Y, Zhang C, Jiang B, Qin Z, Liu Z, Yang Y
Evaluation of all-for-one tourism development level: Evidence from Xinjiang production and construction corps, China.
PLoS One: 2025, 20(4);e0317834
[PubMed:40173197] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Valentin O, Foster NEV, Intartaglia B, Prud'homme MA, Schönwiesner M, Nozaradan S, Lehmann A
Intact sensorimotor rhythm abilities but altered audiovisual integration in cochlear implant users.
PLoS One: 2025, 20(4);e0320815
[PubMed:40173130] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Schoeller FA, Christov-Moore L, Lynch C, Jain A, Diot T, Reggente N
Repeated exposure decreases aesthetic chills likelihood but increases intensity.
PLoS One: 2025, 20(4);e0300494
[PubMed:40173129] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Konari AS, Sammadar S, Biswas S
Barriers to Timely Care: Understanding Delayed Health-Seeking Behavior in Chronic Otitis Media Patients in India.
Ear Nose Throat J: 2025 Apr 2;1455613251331837
[PubMed:40173056] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Hoffmann D, Balcaen T, Vangrunderbeeck S, Puigdevall Mata L, Maes A, Pyka G, Dumoutier L, Behets C, De Borggraeve W, Kerckhofs G
3D Histological Analysis of Soft Tissues by Contrast-Enhanced X-Ray Microfocus Computed Tomography: Screening and Staining Optimization of Contrast-Enhancing Staining Agents.
Microsc Microanal: 2025 Mar 17, 31(2);
[PubMed:40173054] [WorldCat.org: ISSN ESSN ] [DOI] ( p)

Mukhtyar CB, Ather A, Ducker G, Ecclestone T, Fordham S, Naeem H, Coath FL
A preceptorship programme to learn ultrasonography for diagnosis of giant cell arteritis.
Scand J Rheumatol: 2025 Apr 2;1-6
[PubMed:40173023] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

García-Ramón DF, Cornelio-Santiago HP, Norabuena E, Sumarriva L, Alvarez-Chancasanampa H, Vega MN, Sotelo-Méndez A, Espinoza-Espinoza LA, Pantoja-Tirado LR, Gonzales-Agama SH, Chavarría-Marquez EY, Castro-Galarza CR
Effective novel and conventional technologies for decontamination of aflatoxin B(1) in foods: a review.
Mycotoxin Res: 2025 Apr 2;
[PubMed:40172772] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Pompecki S, Balakirski G, Löser CR
[Nail cosmetics-risks and opportunities].
Dermatologie (Heidelb): 2025 Apr 2;
[PubMed:40172625] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Grigoryan IV, Antiufrieva LA, Grigoryan AP, Pigareva VA, Generalov EA, Khomutov GB, Sybachin AV
IPECnet: ML model for predicting the area of water solubility of interpolyelectrolyte complexes.
Phys Chem Chem Phys: 2025 Apr 2;
[PubMed:40172530] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Zegarra-Flores JA, Condori-Ramos AR, Coloma-Dongo FE, Llatasi EEC, Llatasi FGC, Caceres CGM, Mamani CMC, Areche FO, Paricanaza-Ticona DC, Quispe EET, Leon-Gomez R
Analysis of the innovation system in the adoption of IR-43 (NIR) and Tinajones rice varieties by farmers of the Camaná Valley.
Braz J Biol: 2025, 85;e286882
[PubMed:40172452] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Catisquini EAT, Teixeira MM, Zampronio CDP, Oliveira JRM, Mondelli MFCG, Lourençone LFM, Brito Neto RV
Effect of active middle ear implant on auditory speech perception in individuals with ear malformation.
Codas: 2025, 37(3);e20240032
[PubMed:40172373] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Flumignan VK, Sircili MP, Franzolin MR, Tavassi AMC, Germano LG, Souza AVDS, Silva NF, Fukumasu NK, Anjos RMD, Otoch JP, Artifon ELA
Comparison between biliary plastic stents with and without application of silver nanoparticles: an in-vitro study of the biofilm formation.
Acta Cir Bras: 2025, 40;e402825
[PubMed:40172368] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Baysal F, Poschner T, Längle S, Edlinger-Stanger M, Sauer J, Andreas M
Total endoscopic valve surgery with the Ram device in combined mitral and tricuspid valve disease.
Multimed Man Cardiothorac Surg: 2025 Apr 2, 2025;
[PubMed:40172328] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Hodaei M, Mandelis A, Cheung AM
Bone ultrasound fractal dimension theory and experimental analysis with application to early osteoporosis prediction in cancellous bone.
J Acoust Soc Am: 2025 Apr 1, 157(4);2440-2460
[PubMed:40172278] [WorldCat.org: ISSN ESSN ] [DOI] ( p)

Nagata JM, Lee CM, Hur JO, Baker FC
What we know about screen time and social media in early adolescence: a review of findings from the Adolescent Brain Cognitive Development Study.
Curr Opin Pediatr: 2025 Apr 2;
[PubMed:40172268] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Rimple PA, Olafsson EB, Markus BM, Wang F, Augusto L, Lourido S, Carruthers VB
Metabolic adaptability and nutrient scavenging in Toxoplasma gondii: insights from ingestion pathway-deficient mutants.
mSphere: 2025 Apr 2;e0101124
[PubMed:40172222] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Shull LM, Wolter DJ, Kunkle DE, Legg KA, Giedroc DP, Skaar EP, Hoffman LR, Reniere ML
Analysis of genetic requirements and nutrient availability for Staphylococcus aureus growth in cystic fibrosis sputum.
mBio: 2025 Apr 2;e0037425
[PubMed:40172197] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Watson RG, Hole CR
Simple growth conditions improve targeted gene deletion in Cryptococcus neoformans.
mSphere: 2025 Apr 2;e0107024
[PubMed:40172186] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Rahmatian N, Abbasi S, Abbasi N, Tavakkoli Yaraki M
A green carbon dot@silver nanoparticle hybrid: as a turn-on fluorescent probe for the detection and quantification of cholesterol and glucose.
Nanoscale: 2025 Apr 2;
[PubMed:40171805] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Said SM, Mashadi AH, Gabr MA, Elderie A, Sanad M
Modified Ross procedure with four different strategies for right ventricular outflow tract reconstruction.
Multimed Man Cardiothorac Surg: 2025 Apr 2, 2025;
[PubMed:40171624] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Quero-Jiménez PC, Hernández-Ramírez A, Gomes G, Guzmán-Mar JL, Maia-Bila D, Hinojosa-Reyes L
A bentonite/ZIF-8 derived ZnO photocatalyst for the effective elimination of a mixture of endocrine disruptors under simulated solar light: estrogenicity mitigation.
Dalton Trans: 2025 Apr 2;
[PubMed:40171614] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Chen M, Pelras T, Benninga J, Voet VSD, Folkersma R, Loos K
Glycosylated polyplex micelles from oppositely charged block copolymers.
J Mater Chem B: 2025 Apr 2;
[PubMed:40171603] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Qtait M
Time Wasters Facing Nurses During Work in Hospital Departments.
SAGE Open Nurs: 2025 Jan-Dec, 11;23779608251328278
[PubMed:40171549] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Steers MN, Strowger M, Tanygin AB, Ward RM, Nolfi DA
The Relationship Between Alcohol-Related Content on Social Media and Alcohol Outcomes in Young Adults: A Scoping Review.
Alcohol Res: 2025, 45(1);04
[PubMed:40171547] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Angelini F, Gini G
Digital stress and friendship conflict in adolescence: the role of perceived norms and features of social media.
Front Digit Health: 2025, 7;1497222
[PubMed:40171529] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Yu J, Zhao Y
Health messages that engage audiences after the COVID-19 pandemic: content analysis of Chinese posts on social media.
Front Public Health: 2025, 13;1533390
[PubMed:40171439] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Khoza-Shangase K, Mokhethi K
Recreational noise induced hearing loss: South African undergraduate students' perspectives.
Front Public Health: 2025, 13;1534731
[PubMed:40171431] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Dunson BT, Zaki DP, Blondin MS, Duet ML, Steele T, Pestana CV, Pestana IA
Crowdsourced Comparison of Aesthetic Outcomes of Traditional Transverse Versus Skin-Reducing Mastectomy Incision Patterns Following Implant-Based Breast Reconstruction.
Cureus: 2025 Mar, 17(3);e79924
[PubMed:40171343] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Wack M, Ehrett C, Linvill D, Warren P
Generative propaganda: Evidence of AI's impact from a state-backed disinformation campaign.
PNAS Nexus: 2025 Apr, 4(4);pgaf083
[PubMed:40171239] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Kristensen-McLachlan RD, Canavan M, Kárdos M, Jacobsen M, Aarøe L
Are chatbots reliable text annotators? Sometimes.
PNAS Nexus: 2025 Apr, 4(4);pgaf069
[PubMed:40171238] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Kemp KC, Altundal ÖF, Jo D, Huang W, Wang Q, Deng F, Sastre G, Hong SB
The role of structural defects in the fluoride-mediated synthesis of aluminosilicate zeolites.
Chem Sci: 2025 Mar 25;
[PubMed:40171031] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Biehler E, Pagola S, Stam D, Merkelbach J, Jandl C, Abdel-Fattah TM
A comparison of microcrystal electron diffraction and X-ray powder diffraction for the structural analysis of metal-organic frameworks.
J Appl Crystallogr: 2025 Apr 1, 58(Pt 2);398-411
[PubMed:40170975] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Sasikala D, Baghkomeh PN, Farzan JM, Nuvvula S, Arockiam S
Use of social media by parents as a resource for knowledge on children's oral health: a systematic review.
Can J Dent Hyg: 2025 Feb, 59(1);45-58
[PubMed:40170949] [WorldCat.org: ISSN ESSN ] ( )

Weese JS
Canine contact networks: A survey-based study of dog contacts and activities.
Can Vet J: 2025 Apr, 66(4);417-424
[PubMed:40170947] [WorldCat.org: ISSN ESSN ] ( p)

Sistu H, Holden JF
Formate addition enhanced hydrogen production by Thermococcus paralvinellae when grown on brewery wastewater.
Front Microbiol: 2025, 16;1560780
[PubMed:40170917] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Ratajczak-Pawłowska AE, Szymczak-Tomczak A, Hryhorowicz S, Zawada A, Skoracka K, Rychter AM, Skrzypczak-Zielińska M, Słomski R, Dobrowolska A, Krela-Kaźmierczak I
Relationship of visfatin with obesity and osteoporosis in patients with inflammatory bowel disease: a narrative review.
Front Immunol: 2025, 16;1533955
[PubMed:40170859] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Bontrager DR, Christie JT, Pierce AJ, Artchawakom T, Waengsothorn S, Jones MD
Ritualistic Male-Male Combat of the Northern King Cobra (Ophiophagus hannah) in Thailand.
Ecol Evol: 2025 Apr, 15(4);e71191
[PubMed:40170832] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Sato S, Teramura Y, Ogawa Y, Shimizu E, Otake M, Hori K, Kamata T, Shu Y, Seta Y, Kuramochi A, Asai K, Shimizu S, Negishi K, Hirayama M
Conditioned media of stem cells from human exfoliated deciduous teeth contain factors related to extracellular matrix organization and promotes corneal epithelial wound healing.
Regen Ther: 2025 Jun, 29;148-161
[PubMed:40170802] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Patel MN, Patel N, Merja A
Advancing Hair Regrowth Assessment: Development and Standardization of Methods for Evaluating New Hair Growth, Hair Keratin Levels, and Scalp Health in Androgenetic Alopecia Patients.
Cureus: 2025 Feb, 17(2);e79859
[PubMed:40170743] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Woollard L, Gorman R
The emerging need to manage patient expectations of haemophilia gene therapy amidst media hype in the UK.
Ther Adv Rare Dis: 2025 Jan-Dec, 6;26330040251330317
[PubMed:40170737] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Shayan-Moghadam R, Sherafatvaziri A, Vosoughi F, Mirzamohamadi A, Saffar H, Shafieian M, Zanjani LO, Nematian H, Nabian MH
Optimum storage conditions for osteochondral allograft plugs: An ex vivo comparative study of 12 storage protocols.
J Exp Orthop: 2025 Apr, 12(2);e70206
[PubMed:40170704] [WorldCat.org: ISSN ESSN ] [DOI] ( )

Singh R, Katyal M, Mahajan R, Gupta R, Aggarwal NK, Yadav A
Valorization of Pomace Waste for the Production of Cellulose by Komagataeibacter diospyri RSA4.
Biotechnol Appl Biochem: 2025 Apr 1;e2757
[PubMed:40170450] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Kuhney FS, Strauss GP, Walker EF, James SH, Mittal VA
Digital Phenotyping Measurement of Smartphone Social Behavior is Associated with Illness Progression Risk Scores in Young People at Clinical High Risk for Psychosis.
Schizophr Bull: 2025 Apr 2;
[PubMed:40170392] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Ghali H, Krenitsky A, Albers SE
Safety of Petroleum-Based Emollients in Pediatric Atopic Dermatitis.
Clin Pediatr (Phila): 2025 Apr 1;99228251331443
[PubMed:40170321] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Mao Z, Liao X, Ma H
[Databases, knowledge bases, and large models for biomanufacturing].
Sheng Wu Gong Cheng Xue Bao: 2025 Mar 25, 41(3);901-916
[PubMed:40170304] [WorldCat.org: ISSN ESSN ] [DOI] ( p)

Wang M, He Y, Cohen SA, Strohm AR, Haley JD, Walker SG, Alley MRK, Tonge PJ
Time-Dependent Inhibition of Leucyl-tRNA-Synthetase (LeuRS): Insight into Target Vulnerability.
ACS Infect Dis: 2025 Apr 1;
[PubMed:40170302] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Potluru A, Nikookam Y, Guckian J
Comment on 'A Comparison of Large Language Model Powered Search Tools Reveal Differences in Output Quality, Information Transparency, and Accessibility for Mohs Micrographic Surgery Inquiries' - Enhancing Patient Education on Mohs Surgery: The Role of LLMs and Social Media.
Clin Exp Dermatol: 2025 Apr 2;
[PubMed:40170283] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Girgis RR, Hesson H, Appelbaum PS, Brucato G
Cannabis involvement and mass shooting events in the United States from 1900 to 2019.
East Asian Arch Psychiatry: 2025 Mar, 35(1);28-31
[PubMed:40170208] [WorldCat.org: ISSN ESSN ] [DOI] ( p)

Zhao X, Sun SB
Educational Heterogeneity in the Relationship Between Internet Use and Episodic Memory Among Older Adults.
J Geriatr Psychiatry Neurol: 2025 Apr 1;8919887251330311
[PubMed:40170195] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Sun Y, Liao Q, Fan Y, Cui C, Wang Y, Yang C, Hou Y, Zhao D
DCE-MRI radiomics of primary breast lesions combined with ipsilateral axillary lymph nodes for predicting efficacy of NAT.
BMC Cancer: 2025 Apr 1, 25(1);589
[PubMed:40170181] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Asghar Vahedi F, Gholizadeh L, Khajehei M
Knowledge and Awareness of Cardiovascular Risk Factors Among Women With a History of Pregnancy Complications in Australia: A World Heart Federation Cross-Sectional Study.
Aust N Z J Obstet Gynaecol: 2025 Apr 1;
[PubMed:40170108] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Zhang Y, Zheng L, Wang X, Shen X, Feng Y, Niu Y, Cai W
Understanding global mobility of dietetic talents: a survey study of overseas-educated dietetic returnees in China.
Global Health: 2025 Apr 1, 21(1);15
[PubMed:40170102] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Dekhissi A, Taik FZ, Aharrane FZ, Adnine A, Takhrifa N, Fourtassi M, Abourazzak FE
Social media as a source of information for patients with knee osteoarthritis.
BMC Musculoskelet Disord: 2025 Apr 1, 26(1);315
[PubMed:40169994] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Slettmyr A, Schandl A, Arman M, Hugelius K
Fight or flight-intensive care nurses' decisions to resign following the COVID-19 pandemic: a phenomenological hermeneutical study.
BMC Nurs: 2025 Apr 1, 24(1);360
[PubMed:40169987] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Mayo NE, Brouillette MJ, Falcone EL, Fellows LK
A patient-centered view of symptoms, functional impact, and priorities in post-COVID-19 syndrome: cross-sectional results from the Québec Action Post-COVID cohort.
BMC Infect Dis: 2025 Apr 2, 25(1);456
[PubMed:40169972] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Xu C, Wu M, Zhang X, Shen K, Guo Y, Yuan J, Zhu H
Carotid intima thickness and elasticity combined with MHR predicting the severity of coronary artery stenosis in patients with premature coronary artery disease.
BMC Cardiovasc Disord: 2025 Apr 1, 25(1);241
[PubMed:40169942] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Schinaia C
Catastrophism and catastrophic images: Ferenczi's identification with the aggressor and Ogden's autistic-contiguous position as defence mechanisms.
Am J Psychoanal: 2025 Apr 1;
[PubMed:40169868] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Al-Anazi RG, Alzaidi MSA, Eltahir MM, Alkhiri H, Alajmani SH, Darem AA, Alshahrani M, Alhebaishi N
An adaptive search mechanism with convolutional learning networks for online social media text summarization and classification model.
Sci Rep: 2025 Apr 1, 15(1);11058
[PubMed:40169845] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Yun K, Seo Y, Oh Y, Kim S, Maeng HS, Cho JG, Son YB, Son DJ, Kwon K, Kim S, Jo H, Park H
Lysyl-tRNA synthetase 1 promotes atherogenesis via autophagy-related secretion and inflammation.
Sci Rep: 2025 Apr 1, 15(1);11099
[PubMed:40169806] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Shim SR, Shin J, Hwang CM, Kim YK, Park JB, Kim JY
Tranexamic acid in ear surgery: enhancing surgical field visibility and reducing bleeding-a systematic review and meta analysis.
Sci Rep: 2025 Apr 1, 15(1);11132
[PubMed:40169708] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Sultan NA, Hamama HH, Grawish ME, El-Toukhy RI, Mahmoud SH
Impact of different capping materials extracts on proliferation and osteogenic differentiation of cultured human dental pulp stem cells.
Sci Rep: 2025 Apr 1, 15(1);11140
[PubMed:40169700] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Pazoki H, Anbia M
Kinetic and isotherm studies of cr (VI) adsorption from aqueous media by using a synthetic chitosan-allophane nanocomposite.
Sci Rep: 2025 Apr 1, 15(1);11088
[PubMed:40169671] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Chwalek P, Kuronaga M, Zhu I, Montague S, Campopiano Robinson V, Lohrmann J, Gil CAV, Susič D, Gradišek A, Schul J, Paradiso JA, Arbetman M
High-Res Acoustic and Environmental Data to Monitor Bombus dahlbomii Amid Invasive Species, Habitat Loss.
Sci Data: 2025 Apr 1, 12(1);548
[PubMed:40169623] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Evich MG, Ferreira J, Adeyemi O, Schroeder PA, Williams JC, Acrey B, Burdette D, Grieve M, Neill MP, Simmons K, Striggow BC, Cohen SB, Cyterski M, Glinski DA, Henderson WM, Kim DY, Washington JW
Mineralogical controls on PFAS and anthropogenic anions in subsurface soils and aquifers.
Nat Commun: 2025 Apr 1, 16(1);3118
[PubMed:40169557] [WorldCat.org: ISSN ESSN ] [DOI] ( e)

Pablo JN, Shires J, Castellanos J, Kapila M, Kemmelmeier LL, Berryhill ME
Changed detection: No relationship between working memory and media usage in Covid-era and contemporary young adults.
Atten Percept Psychophys: 2025 Apr 1;
[PubMed:40169525] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Ip S, Angelo C, Cohen P, Tinker E, Andronicos A, Dickson M
Smoke-Free Home: Developing an Aboriginal Health Promotion and Social Marketing Campaign in Western Sydney, Australia.
Health Promot J Austr: 2025 Apr, 36(2);e949
[PubMed:40169488] [WorldCat.org: ISSN ESSN ] [DOI] ( p)

Billias N, MacEachen E
Capturing the Perspectives of "Laypeople" on Policy Effectiveness: Employers' and Precariously Employed Workers' Suggested Improvements for the Workers' Compensation System and Work Injury Processes.
J Occup Rehabil: 2025 Apr 1;
[PubMed:40169468] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Yao T, Kobayashi H, Hirai T, Tokuoka Y, Tokoro M, Asayama Y, Suzuki Y, Hatano Y, Ikeda H, Sugimura S, Yamamoto T, Yamada TG, Hosoi Y, Funahashi A, Fukunaga N, Asada Y, Kurimoto K, Yamagata K
Zinc eluted from glassware is a risk factor for embryo development in human and animal assisted reproduction†.
Biol Reprod: 2025 Apr 2;
[PubMed:40169168] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Wu Y, Kemps E, Prichard I
"Mind your figure! Watch, but don't eat": A content analysis of eating and appearance-related messages in eating videos on social media.
Body Image: 2025 Mar 31, 53;101883
[PubMed:40168938] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Han Y, Xiong G, Yang S, Luo X, Zan F, Wu X, Chen G
Role of biogas stirring in alleviating acidification and promoting methanogenesis during the anaerobic digestion of food waste: Macroscale and microscale perspectives.
Waste Manag: 2025 Mar 31, 200;114761
[PubMed:40168895] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Ghosh R, Bernar J
An injection filling method for packing chromatography devices.
J Chromatogr A: 2025 Mar 26, 1749;465913
[PubMed:40168792] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Fadillah D
Unveiling the psychological impact of social media on adolescents in Indonesia: Implications for research and practice.
Asian J Psychiatr: 2025 Mar 25, 107;104463
[PubMed:40168702] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

van der Molen AJ, Laguna JJ, van de Ven AAJM, Vega F
Very rare adverse reactions to intravascular contrast media: From Kounis to sweet syndrome.
Eur J Radiol: 2025 Mar 25, 187;112066
[PubMed:40168697] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

Chakraborty R, Beidelman ET, Klein M, Kobayashi LC, Eyal K, Kabudula CW, Rosenberg M
Expanded child support grant eligibility and later-life mortality among mothers in rural South Africa.
Glob Public Health: 2025 Dec, 20(1);2483870
[PubMed:40168537] [WorldCat.org: ISSN ESSN ] [DOI] ( o)

Hegelmann M, Cokoja M
Two-Phase Epoxidations with Micellar Catalysts: Insights, Limitations, and Perspectives.
Chempluschem: 2025 Apr 1;e202500122
[PubMed:40168424] [WorldCat.org: ISSN ESSN ] [DOI] ( a)

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Ihmels JH, Bergmann S
Challenges and prospects in the analysis of large-scale gene expression data.
Brief Bioinform: 2004 Dec, 5(4);313-27
[PubMed:15606968] [WorldCat.org: ISSN ESSN ] [DOI] ( p)

Ihmels J, Bergmann S, Barkai N
Defining transcription modules using large-scale gene expression data.
Bioinformatics: 2004 Sep 1, 20(13);1993-2003
[PubMed:15044247] [WorldCat.org: ISSN ESSN ] [DOI] ( o)

Bergmann S, Ihmels J, Barkai N
Similarities and differences in genome-wide expression data of six organisms.
PLoS Biol: 2004 Jan, 2(1);E9
[PubMed:14737187] [WorldCat.org: ISSN ESSN ] [DOI] ( o)

Bergmann S, Ihmels J, Barkai N
Iterative signature algorithm for the analysis of large-scale gene expression data.
Phys Rev E Stat Nonlin Soft Matter Phys: 2003 Mar, 67(3 Pt 1);031902
[PubMed:12689096] [WorldCat.org: ISSN ESSN ] [DOI] ( o)

Ihmels J, Friedlander G, Bergmann S, Sarig O, Ziv Y, Barkai N
Revealing modular organization in the yeast transcriptional network.
Nat Genet: 2002 Aug, 31(4);370-7
[PubMed:12134151] [WorldCat.org: ISSN ESSN ] [DOI] ( o)

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1. Kutalik2008NB pmid=18464786 // PDF
2. Ihmels2004 pmid=15606968 // PDF
3. Ihmels2004a pmid=15044247 // PDF
4. Bergmann2004 pmid=14737187 // PDF
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