Difference between revisions of "Neuroenergetics: Importance of transport for the regulation of energy substrate fluxes in brain cells"
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'''Biological or Medical aspects''': The “biology supervisor” will provide background of the main aspects related to brain energy metabolism and Michaelis-Menten kinetics. | '''Biological or Medical aspects''': The “biology supervisor” will provide background of the main aspects related to brain energy metabolism and Michaelis-Menten kinetics. | ||
| − | '''Supervisors''': Luc Pellerin & Aitana Morton de Lachapelle | + | '''Supervisors''': [[Luc Pellerin]] & [[Aitana Morton de Lachapelle]] |
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(Project in [[Course: "Solving Biological Problems that require Math"]]) | (Project in [[Course: "Solving Biological Problems that require Math"]]) | ||
Revision as of 00:56, 14 February 2009
Background: Brain cells were shown to rely on two energy subtrates to sustain their activity: glucose and lactate. Each of these substrates are taken up by brain cells via specific transporters and metabolized in classical biochemical pathways. The critical question remains: Between metabolism and transport, what is the limiting step for the utilization of each energy substrate under resting vs. activated condition?
Goal: The goal of the project is to determine whether transport of the main energy substrates for the brain, glucose and lactate, can become rate-limiting following an increase in cerebral activity.
Mathematical tools: The student will learn to use a mathematical software (Matlab) in order to conduct simulations from a given set of parameters and equations derived from Michaelis-Menten kinetics.
Biological or Medical aspects: The “biology supervisor” will provide background of the main aspects related to brain energy metabolism and Michaelis-Menten kinetics.
Supervisors: Luc Pellerin & Aitana Morton de Lachapelle
(Project in Course: "Solving Biological Problems that require Math")
