Control of mitosis in fission yeast

Background: Fission yeast cells growth up to a given size and then enters mitosis. The question this project addresses is how does the cell knows it has reached to right size for division. This is achieved by a gradient of the pom1 protein along the cortex.

Goal: The goal is to mathematically describe the mechanism by which such a gradient is achieved using differential equation and analyze such gradients from fluorescence microscopy images.

Mathematical tools: Ordinary differential equations, Mathematica, Matlab, ImageJ

Biological or Medical aspects: Pom1 is a protein witch one form a cortical intracellular gradient who permit to control the entry of mitosis of the fission yeast, S.Pombe. The fact is, interaction of pom1 and cdr2 induces a cell cycle delay following to a gene activation cascade. Microtubuls perform

Supervisor: Sascha Dalessi

Students: Degrugillier Lucas, Delapierre Fabien, Merçay Johan.

Presentation:

Final Report:

References: <biblio>

1. hachet10 pmid=21703453

</biblio> <biblio>

1. Morphogen Gradient Formation

</biblio> <biblio>

1. Polar gradients of the DYRK-family kinase Pom1 couple cell length with the cell cycle

</biblio> http://www.sciencedirect.com/science/article/pii/S009286741100540X

Back to UNIL BSc course: "Solving Biological Problems that require Math 2012"]