Control of mitosis in fission yeast
Background: Fission yeast cells growth up to a given size and then enters mitosis. The question this project addresses is how does the cell knows it has reached to right size for division. This is achieved by a gradient of the pom1 protein along the cortex.
Goal: The goal is to mathematically describe the mechanism by which such a gradient is achieved using differential equation and analyze such gradients from fluorescence microscopy images.
Mathematical tools: Ordinary differential equations, Mathematica, Matlab
Biological or Medical aspects: Pom1 is a protein which forms a cortical intracellular gradient that permits to control the entry of mitosis of the fission yeast, S. Pombe. The fact is, interaction of pom1 and cdr2 induces a cell cycle delay following to a gene activation cascade. Microtubuls performs
Supervisor: Sascha Dalessi
Students: Degrugillier Lucas, Delapierre Fabien, Merçay Johan.
Presentation:
Final Report:
References:
<biblio>
- hachet10 pmid=21703453
- Martin SG, Berthelot-Grosjean M. Polar gradients of the DYRK-family kinase Pom1 couple cell length with the cell cycle. Nature. 2009 Jun 11;459(7248):852-6. Epub 2009 May 27. pmid:19474792. PubMed
- Wartlick O, Kicheva A, González-Gaitán M. Morphogen gradient formation. Cold Spring Harb Perspect Biol. 2009 Sep;1(3):a001255. pmid:20066104 PubMed
</biblio>
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