WingX: Systems Biology of the Drosophila Wing

Some people of our group are part of the Swiss WingX project. The goal of this project is to generate quantitative datasets that serve as input for multi-scale modeling approaches of wing development and morphogenesis. These models will make experimentally testable predictions on the biophysical properties and molecular regulatory circuits that control the basic size and shape of the wing. In our group, we will investigate among other things how (and how much!) robustness is achieved during wing imaginal disc patterning.

Introductory reading

• Introduction to Systems Biology, Uri Alon
• Developmental Biology, Gilbert

Recommended reading

Morphogens

• Review on morphogens ibaneztabata
• Review on Dpp gradient formation affbasler and Dpp kinetics kicheva
• Dpp gradient formation with transcytosis entchev (for modeling details, see krusebollenbach) and facilitated (restricted) external diffusion belenkaya
• Dpp precision and scaling bollenbach
• Wingless gradient formation striginicohen (see hufnagel for modeling)

Growth and size regulation

• From the tissue perspective aegerter
• From the cellular perspective farhadifar

References

<biblio>

1. ibanez pmid=18364710
2. tabata pmid=14757636
3. affbasler pmid=17703237
4. kicheva pmid=17255514
5. entchev pmid=11136982
6. kruse pmid=15358671

</biblio>