User:PedroMarquesVidal
Contact
Pedro Marques-Vidal Chef de Clinique Adjoint Institut Universitaire de Médecine Sociale et Préventive 17, rue du Bugnon 1005 Lausanne Phone: +41 21 314 72 65 Fax: +41 21 314 73 73 Email: Pedro-Manuel.Marques-Vidal@chuv.ch
Topic
Goal: The goal of the project is to perform a genome-wide association study that will potentially identify SNPs that are related to tobacco consumption and related phenotypes. Particular emphasis will be put on SNP tagging taste-specific genes such as the TAS2R.
Mathematical tools: The tool of choice for this project is logistic regression analysis. The student will learn the basics of regressing a given phenotype to a genotype and how this analysis is implemented on a computer to handle a large number of SNPs. If time permits the student will explore the effect of other phenotypes as covariables and/or environmental interactions.
References
Kim U, Wooding S, Ricci D, Jorde LB, Drayna D. Worldwide haplotype diversity and coding sequence variation at human bitter taste receptor loci. Hum Mutat. 2005 Sep;26(3):199-204 Mangold JE, Payne TJ, Ma JZ, Chen G, Li MD. Bitter taste receptor gene polymorphisms are an important factor in the development of nicotine dependence in African Americans. J Med Genet. 2008 Sep;45(9):578-82. Epub 2008 Jun 4 Snedecor SM, Pomerleau CS, Mehringer AM, Ninowski R, Pomerleau OF. Differences in smoking-related variables based on phenylthiocarbamide "taster" status. Addict Behav. 2006 Dec;31(12):2309-12
