Difference between revisions of "Narcolepsy"
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<newstitle>Genome-wide Association Study reveals new HLA-haplotype strongly protective against narcolepsy</newstitle> | <newstitle>Genome-wide Association Study reveals new HLA-haplotype strongly protective against narcolepsy</newstitle> | ||
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| − | In collaboration with Mehdi Tafti's research group we have published our recent discovery on a newly identified HLA haplotype that protects individuals from narcolepsy even if they carry the famous risk haplotype. Our article appeared online in | + | In collaboration with Mehdi Tafti's research group we have published our recent discovery on a newly identified HLA haplotype that protects individuals from narcolepsy even if they carry the famous risk haplotype. Our article appeared online in <a href="http://www.nature.com/ng/journal/vaop/ncurrent/abs/ng.647.html">Nature Genetics</a> on 15 August 2010. |
<date>16 Aug 2010 — 11:45</date> | <date>16 Aug 2010 — 11:45</date> | ||
</teaser> | </teaser> | ||
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| − | + | 20711174 | |
</pubmed> | </pubmed> | ||
Latest revision as of 16:07, 20 August 2012
We are involved in a Genome-wide Association Study on narcolepsy conducted by Mehdi Tafti's Group at the University of Lausanne. In brief, we identified a haplotype in the HLA-region that is strongly protective against narcolepsy. More than 10% of HLA-positive controls carry this DRB1*1301-DQB1*0603 haplotype, which was found in virtually no narcoleptic cases. The research findings were published in Nature Genetics.
Hor H, Kutalik Z, Dauvilliers Y, Valsesia A, Lammers GJ, Donjacour CE, Iranzo A, Santamaria J, Peraita Adrados R, Vicario JL, Overeem S, Arnulf I, Theodorou I, Jennum P, Knudsen S, Bassetti C, Mathis J, Lecendreux M, Mayer G, Geisler P, Benetó A, Petit B, Pfister C, Bürki JV, Didelot G, Billiard M, Ercilla G, Verduijn W, Claas FH, Vollenweider P, Waeber G, Waterworth DM, Mooser V, Heinzer R, Beckmann JS, Bergmann S, Tafti M
Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy.
Nat Genet: 2010 Sep, 42(9);786-9
[PubMed:20711174]
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