Difference between revisions of "Modelling pathways crosstalks as closed walks and cycles on graphs"
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==Modelling pathways crosstalk in gene/protein networks as closed walks & cycles on graphs== | ==Modelling pathways crosstalk in gene/protein networks as closed walks & cycles on graphs== | ||
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| + | =Definitions= | ||
| + | Our project was to analyse and quantify interactions between different biological pathways. Those interactions are named closed walks. A closed walks is a sequence of interactions between genes that starts and ends at the same gene. A cycle is a closed walk that never goes twice through the same gene except for the gene from which the interactions start and end. A cross talk is a closed walk that goes through genes from two different pathways, meaning that those pathways communicate and regulate each other through their genes/proteins interactions. | ||
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| + | =Research questions= | ||
| + | We had 3 research questions: | ||
| + | * Are some functional pathways more prone to crosstalk than the others? If so, which ones? | ||
| + | * What are the genes that are apparent “entry points” for the crosstalk with other pathways? | ||
| + | * Is crosstalk a symmetric process, i.e. do both pathways “need each other” the same, or is one rather “exploiting” the other for input stimuli? | ||
Revision as of 09:33, 4 June 2024
Modelling pathways crosstalk in gene/protein networks as closed walks & cycles on graphs
Definitions
Our project was to analyse and quantify interactions between different biological pathways. Those interactions are named closed walks. A closed walks is a sequence of interactions between genes that starts and ends at the same gene. A cycle is a closed walk that never goes twice through the same gene except for the gene from which the interactions start and end. A cross talk is a closed walk that goes through genes from two different pathways, meaning that those pathways communicate and regulate each other through their genes/proteins interactions.
Research questions
We had 3 research questions:
- Are some functional pathways more prone to crosstalk than the others? If so, which ones?
- What are the genes that are apparent “entry points” for the crosstalk with other pathways?
- Is crosstalk a symmetric process, i.e. do both pathways “need each other” the same, or is one rather “exploiting” the other for input stimuli?
