Gene Expression Signatures 101 - The PAM50 gene expression signature

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  • Title: "Gene Expression Signatures 101 - The PAM50 gene expression signature"
  • Papers to be examined:

Perou, C. M. et al. (2000) Molecular portraits of human breast tumours. Nature, 406(6797), 747–752.

Parker, J. S. et al. (2009) Supervised Risk Predictor of Breast Cancer Based on Intrinsic Subtypes. Journal of Clinical Oncology, 27(8), 1160–1167.

Gatza, M. L. et al. (2014) An integrated genomics approach identifies drivers of proliferation in luminal-subtype human breast cancer. Nature Genetics, 46(10), 1051–1059

  • Data and Code: Day 1 Day 2 Day 3
  • Key bioinformatics concept of this module: "What are gene expression signatures (GES). How GES are created and used."